THE PATHOLOGIC EFFECTS OF INTRAVENOUSLY ADMINISTERED SOLUBLE ANTIGEN-ANTIBODY COMPLEXES

Author:

Benacerraf Baruj1,Potter Jacobus L.1,McCluskey Robert T.1,Miller Frederick1

Affiliation:

1. From the Department of Pathology, New York University—Bellevue Medical Center, New York

Abstract

The intravenous administration to rats of soluble antigen-antibody complexes in antigen excess resulted in acute glomerulonephritis. This occurred with both rabbit antiovalbumin and rabbit anti-BSA systems. The rats so treated regularly showed proteinuria and elevation of blood urea nitrogen. These findings are compared with those reported in rats injected with anti-kidney serum.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

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