Affiliation:
1. From the H. K. Cushing Laboratory of Experimental Medicine in the Department of Medicine of Western Reserve University School of Medicine and Lakeside Hospital, Cleveland
Abstract
1. During normal growth of the rabbit heart, muscle fibers enlarge, and the capillaries multiply so that a relatively constant capillary supply per unit of tissue is maintained from the time of birth to maturity.
2. In cardiac hypertrophy the muscle fibers enlarge, but the capillaries do not multiply and, as a result, the capillary supply per unit of tissue is reduced.
3. The decreased concentration of capillaries in the hypertrophied heart would constitute an impediment to the adequate exchange of metabolic substances, but the seriousness of the impediment cannot be estimated without further physiological data.
Publisher
Rockefeller University Press
Subject
Immunology,Immunology and Allergy
Cited by
125 articles.
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