CIRRHOSIS OF THE LIVER CAUSED BY EXCESS DIETARY CYSTINE

Author:

Earle David P.1,Victor Joseph1

Affiliation:

1. From the Research Service, First Division, Welfare Hospital, Department of Hospitals, City of New York, and the Department of Medicine, College of Physicians and Surgeons, Columbia University, New York

Abstract

1. Cystine fed to young albino rats as 10 per cent of the diet resulted in: (a) Portal hemorrhagic necrosis, resembling eclampsia, within 3 or 4 days. (b) A high mortality rate. (c) Fatty infiltration of hepatic cells in all rats surviving the initial acute lesion. (d) Cirrhosis of the liver in rats surviving more than 2 weeks. 2. 5 per cent dietary cystine produced marked fatty infiltration of the liver, followed by portal hemorrhagic necrosis. Cirrhosis was present in one of the two rats on the diet for 6 weeks. 3. The livers of rats fed 5 or 10 per cent cystine diets followed by the McCollum stock diet, showed evidence of residual cellular damage, and of regeneration as shown by mitotic figures. 4. In this series of 30 rats on excess dietary cystine, a renal lesion was found in only one case.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Cited by 47 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. EXPERIMENTAL PORTAL CIRRHOSIS;Acta Pathologica Microbiologica Scandinavica;2009-08-18

2. The l-Methionine-Sparing Effect of Dietary Glutathione in Rats;The Journal of Nutrition;1982-12-01

3. Effects of ingestion of disproportionate amounts of amino acids.;Physiological Reviews;1970-07

4. Fatty livers and lipotropic phenomena;Progress in the Chemistry of Fats and other Lipids;1970-01

5. FIBROSIS WITH BILE DUCT PROLIFERATION IN RAT LIVER BY ORAL ADMINISTRATION OF EXCESS GLUCOSE-CYSTEINE*;Pathology International;1968-08

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