A20 takes on tumors: tumor suppression by an ubiquitin-editing enzyme-Reference-Cited by-同舟云学术

A20 takes on tumors: tumor suppression by an ubiquitin-editing enzyme

Published:2009-04-20 Issue:5 Volume:206 Page:977-980
ISSN:1540-9538
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Malynn Barbara A.¹,Ma Averil¹

Affiliation:

1. B.A.M. and A.M. are at Program in Biomedical Sciences, Program in Biological Sciences, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143.

Abstract

Many B cell cancers are characterized in part by the dysregulation of the NF-κB signaling pathway. A new study identifies somatic mutations in TNFAIP3, the gene encoding the NF-κB inhibitor A20, in Hodgkin lymphomas and primary mediastinal lymphomas. These data reveal the role of A20 as a tumor suppressor protein.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Link

http://rupress.org/jem/article-pdf/206/5/977/1200515/jem_20090765.pdf

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