Affiliation:
1. D.V. and V.M.D. are at Department of Protein Engineering and Department of Physiological Chemistry, Genentech, Inc., South San Francisco, CA 94080
Abstract
A key feature of aggressive B cell lymphomas is constitutive NF-κB activation, which requires signals from the CARD11–BCL-10–MALT1 (CMB) complex. The unique enzymatic activity of MALT1 degrades one of its binding partners, BCL-10, as well as the NF-κB inhibitor A20. New data shows that targeting MALT1 protease activity may be a promising therapeutic strategy for treating aggressive B cell lymphomas.
Publisher
Rockefeller University Press
Subject
Immunology,Immunology and Allergy
Cited by
17 articles.
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