Soothing signals: transplacental transmission of resistance to asthma and allergy-Reference-Cited by-同舟云学术

Soothing signals: transplacental transmission of resistance to asthma and allergy

Published:2009-12-07 Issue:13 Volume:206 Page:2861-2864
ISSN:1540-9538
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Holt Patrick G.¹,Strickland Deborah H.¹

Affiliation:

1. Telethon Institute for Child Health Research, Centre for Child Health Research, the University of Western Australia, Perth 6872, Australia

Abstract

The progressive rise in the prevalence of allergic diseases since the 1970s is widely attributed to diminished exposure to microbial stimuli, resulting in dysregulated immune functions during early life. Most studies investigating the mechanism behind this phenomenon have focused on postnatal microbial exposure. But emerging evidence suggests that such programming may also occur in the developing fetus as a result of microbial stimulation of the pregnant mother.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Link

http://rupress.org/jem/article-pdf/206/13/2861/1200178/jem_20092469.pdf

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4. Dendritic cell entrapment within the pregnant uterus inhibits immune surveillance of the maternal/fetal interface in mice;Collins;J. Clin. Invest.,2009

5. Maternal TLR signaling is required for prenatal asthma protection by the non-pathogenic microbe Acinetobacter lwoffii F78;Conrad;J. Exp. Med.,2009

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