THE ASSOCIATIVE REACTIONS OF PNEUMONIA VIRUS OF MICE (PVM) AND INFLUENZA VIRUSES: THE EFFECTS OF pH AND ELECTROLYTES UPON VIRUS-HOST CELL COMBINATIONS

Abstract

Combination between PVM and erythrocytes as well as between the influenza viruses and erythrocytes is inhibited at low electrolyte concentrations. Combination between PVM and lung particles as well as between the virus and erythrocytes can be dissociated in solutions of low electrolyte concentration. The rate of elution of influenza virus is decreased under similar conditions. PVM can combine with and be dissociated from erythrocytes repeatedly without affecting the combining capacity of the ceils and does not possess an enzyme-like activity similar to that of the influenza viruses. Because dissociation depends on electrolyte concentration and pH, it appears that the PVM-cell component complex may be in the nature of a weak salt.