Cross-Sensitivity between Paroxetine and Sertraline-Reference-Cited by-同舟云学术

Cross-Sensitivity between Paroxetine and Sertraline

Published:2002-04 Issue:4 Volume:36 Page:631-633
ISSN:1060-0280
Container-title:Annals of Pharmacotherapy
language:en
Short-container-title:Ann Pharmacother

Author:

Warnock Caroline A¹,Azadian Abbas G²

Affiliation:

1. Caroline A Warnock BScPhm, Clinical Pharmacist, Department of Pharmaceutical Services, Centre for Addiction and Mental Health, Toronto, Ontario, Canada

2. Abbas G Azadian MD FRCPC, Staff Psychiatrist, Centre for Addiction and Mental Health; Lecturer, Department of Psychiatry, University of Toronto, Toronto

Abstract

OBJECTIVE: To report a case of possible cross-sensitivity between selective serotonin-reuptake inhibitors (SSRIs). CASE SUMMARY: A 20-year-old Southeast Asian man developed a maculopapular rash soon after starting paroxetine. Following resolution of this rash, another skin reaction with the same distribution and appearance occurred after sertraline therapy was started. DISCUSSION: Cross-reactivity between drugs with similar structures has been reported; however, cross-reactivity among SSRI antidepressants is unexpected given their differences in chemical structure. CONCLUSIONS: The possibility of cross-reactivity between SSRI antidepressants should be considered by clinicians who wish to switch from one SSRI to another due to a dermatologic reaction.

Publisher

SAGE Publications

Subject

Pharmacology (medical)

Link

http://journals.sagepub.com/doi/pdf/10.1345/aph.1A262

Reference7 articles.

1. Allergic Reactions to Drugs and Biologic Agents

2. A method for estimating the probability of adverse drug reactions

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