Antipyretic Efficacy and Safety of Ibuprofen and Acetaminophen in Children-Reference-Cited by-同舟云学术

Antipyretic Efficacy and Safety of Ibuprofen and Acetaminophen in Children

Published:2004-01 Issue:1 Volume:38 Page:146-150
ISSN:1060-0280
Container-title:Annals of Pharmacotherapy
language:en
Short-container-title:Ann Pharmacother

Author:

Goldman Ran D¹,Ko Karen²,Linett Lauren J³,Scolnik Dennis⁴

Affiliation:

1. Ran D Goldman MD, Director, Pediatric Research in Emergency Therapeutics (PRETx) Program Division of Pediatric Emergency Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada

2. Karen Ko BSc, Researcher, Division of Pediatric Emergency Medicine, The Hospital for Sick Children

3. Lauren J Linett BSc, Researcher, Division of Pediatric Emergency Medicine, The Hospital for Sick Children

4. Dennis Scolnik MBChB, Staff Physician, Division of Pediatric Emergency Medicine, The Hospital for Sick Children

Abstract

OBJECTIVE: To evaluate the antipyretic effects and safety of ibuprofen compared with acetaminophen in febrile children. DATA SOURCES: Searches of MEDLINE (1966–November 2003) and EMBASE (1988–November 2003) were conducted using the terms ibuprofen and acetaminophen. Bibliographies of selected articles were reviewed. DATA SYNTHESIS: Ibuprofen was significantly more effective than acetaminophen in reducing fever after a single dose. Ibuprofen was found to be more effective after 6 hours, but not after a longer period of time. Studies with multiple doses have also failed to show that one drug is better than the other. CONCLUSIONS: The efficacy and effectiveness of acetaminophen and ibuprofen in their recommended dosages are similar, with slightly more beneficial effects shown with ibuprofen.

Publisher

SAGE Publications

Subject

Pharmacology (medical)

Link

http://journals.sagepub.com/doi/pdf/10.1345/aph.1C391

Reference23 articles.

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3. Fever Phobia Revisited: Have Parental Misconceptions About Fever Changed in 20 Years?

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