Management of Asymptomatic Bacteriuria in Patients with Diabetes Mellitus

Author:

Ooi Say-Tat1,Frazee Lawrence A2,Gardner William G3

Affiliation:

1. Say-Tat Ooi MD, Internal Medicine Resident, Akron General Medical Center, Akron, OH

2. Lawrence A Frazee PharmD, Pharmacotherapy Specialist, Internal Medicine, Akron General Medical Center; Associate Professor of Clinical Pharmacology in Internal Medicine, Northeastern Ohio Universities College of Medicine, Akron

3. William G Gardner MD FACP, Chair, Department of Internal Medicine, Akron General Medical Center; Professor of Medicine, Northeastern Ohio Universities College of Medicine

Abstract

OBJECTIVE To review the literature regarding the management of asymptomatic bacteriuria (ASB) in patients with diabetes mellitus. DATA SOURCES A MEDLINE (1967–June 2003) and bibliographic search of the English-language literature was conducted using the search terms diabetes mellitus, asymptomatic, bacteriuria, and urinary tract infection. DATA SYNTHESIS ASB occurs in diabetic women more commonly than in non-diabetics and is associated with an increased risk of symptomatic urinary tract infection (UTI) among patients with type 2 diabetes. Symptomatic UTIs tend to follow a more complicated course in diabetics. Despite these independent observations, antimicrobial therapy has not been shown to reduce symptomatic UTIs, pyelonephritis, or hospitalization for UTI. CONCLUSION Available evidence does not support antimicrobial treatment of ASB among patients with diabetes mellitus.

Publisher

SAGE Publications

Subject

Pharmacology (medical)

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