Tacrolimus: An Alternative for Graft-Versus-Host Disease Prevention-Reference-Cited by-同舟云学术

Tacrolimus: An Alternative for Graft-Versus-Host Disease Prevention

Published:2000-03 Issue:3 Volume:34 Page:377-381
ISSN:1060-0280
Container-title:Annals of Pharmacotherapy
language:en
Short-container-title:Ann Pharmacother

Author:

Lee Traci J¹,Kennedy LeAnne D²

Affiliation:

1. Traci J Lee PharmD, at time of writing, Pharmacy Practice Resident, Wake Forest University Baptist Medical Center, Winston-Salem, NC; now, Associate Drug Information Product Manager, Product Information Department, SmithKline Beecham Pharmaceuticals, Philadelphia, PA

2. LeAnne D Kennedy PharmD, Pharmaceutical Care Coordinator, Oncology, Wake Forest University Baptist Medical Center, Winston-Salem

Abstract

OBJECTIVE: To evaluate the efficacy of tacrolimus for prevention of graft-versus-host disease (GVHD) in patients receiving allogeneic bone marrow transplants. DATA SOURCES: Published literature was identified through MEDLINE (January 1990–December 1998) using the key words tacrolimus, FK506, graft-versus-host disease, and bone marrow transplant. DATA SYNTHESIS: GVHD associated with allogeneic bone marrow transplant is a serious life-threatening complication. An evaluation of studies using tacrolimus for prevention of GVHD was conducted. CONCLUSIONS: Tacrolimus is effective for the prevention of GVHD in allogeneic bone marrow transplant. Further studies need to be conducted to optimize the dosage schedule and to determine therapeutic ranges, efficacy, and safety.

Publisher

SAGE Publications

Subject

Pharmacology (medical)

Link

http://journals.sagepub.com/doi/pdf/10.1345/aph.18417

Reference16 articles.

1. MARROW TRANSPLANTATION FROM HLA-MATCHED UNRELATED DONORS FOR TREATMENT OF HEMATOLOGIC MALIGNANCIES

2. Methotrexate and Cyclosporine Compared with Cyclosporine Alone for Prophylaxis of Acute Graft versus Host Disease after Marrow Transplantation for Leukemia

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