Influence of Warfarin on Symptoms of Fatigue: Findings of a Randomized Trial

Author:

Kovacs Michael J1,Kearon Clive2,Julian Jim A3,Douketis James D4,Demers Christine5,Wells Philip S6,Turpie Alexander G7,Anderson David R8,Kahn Susan R9,v Nguyen Paul10,Green David11,Kassis Jeannine12,Geerts William13,MacKinnon Betsy14,Ginsberg Jeffrey S15

Affiliation:

1. Michael J Kovacs MD, Associate Professor, Department of Medicine, University of Western Ontario, London, Ontario, Canada

2. Clive Kearon MB PhD, Professor, Department of Medicine, McMaster University, Hamilton, Ontario

3. Jim A Julian MMath, Associate Professor, Department of Clinical Epidemiology and Biostatistics, McMaster University

4. James D Douketis MD, Associate Professor, Department of Medicine, St. Joseph's Hospital, McMaster University

5. Christine Demers MD, Clinical Professor, Department of Medicine, Laval University, Québec City, Québec, Canada

6. Philip S Wells MD MSc, Chief, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario; Senior Scientist, Ottawa Health Research Institute, Ottawa

7. Alexander G Turpie MD, Professor, Department of Medicine, McMaster University

8. David R Anderson MD, Associate Professor, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada

9. Susan R Kahn MD, Associate Professor, Department of Medicine, McGill University, Montreal

10. Paul v Nguyen MD, Associate Professor, Department of Medicine, University of Montreal, Montreal

11. David Green MD PhD, Professor of Medicine, Department of Medicine, Division of Hematology/Oncology, Feinberg School of Medicine of Northwestern University, Chicago, IL

12. Jeannine Kassis MD, Associate Professor, Department of Medicine, University of Montreal

13. William Geerts MD, Associate Professor of Medicine, University of Toronto, Toronto, Ontario

14. Betsy MacKinnon MSc, Research Co-ordinator, Henderson Research Centre, McMaster University

15. Jeffrey S Ginsberg MD, Professor, Department of Medicine, McMaster University

Abstract

BACKGROUND: Some patients develop fatigue while taking warfarin, but causality is uncertain. OBJECTIVE: To assess whether warfarin use is associated with fatigue. METHODS: This investigation was a substudy of a randomized double-blind trial in 13 outpatient thromboembolism clinics. Subjects who had received one month of open-label warfarin therapy for venous thromboembolism due to a transient risk factor were randomly assigned to receive warfarin or placebo for 2 months and followed for another 9 months after stopping the study drug. Fatigue was measured using a Likert scale, and change of fatigue was measured by the patient's global rating. RESULTS: In 87 subjects, the overall ratings of fatigue were 0.1 unit lower (95% CI 0.6 units lower to 0.4 units higher) while taking warfarin. Global rating for change in fatigue intensity showed no increase of fatigue with warfarin use. CONCLUSIONS: The short-term use of warfarin was not associated with symptoms of fatigue.

Publisher

SAGE Publications

Subject

Pharmacology (medical)

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Fatigue after initiating rivaroxaban for venous thromboembolism;Research and Practice in Thrombosis and Haemostasis;2020-03-09

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