Priapism Associated with Zuclopenthixol-Reference-Cited by-同舟云学术

Priapism Associated with Zuclopenthixol

Published:2002-06 Issue:6 Volume:36 Page:1016-1018
ISSN:1060-0280
Container-title:Annals of Pharmacotherapy
language:en
Short-container-title:Ann Pharmacother

Author:

Salado Julio¹,Blázquez Antonio²,Díaz-Simón Raquel³,López-Muñoz Francisco⁴,Alamo Cecilio⁵,Rubio Gabriel⁶

Affiliation:

1. Julio Salado MD, Psychiatrist, Medical Staff, Complejo Asistencial “Benito Menni,” Ciempozuelos, Spain

2. Antonio Blázquez MD, Psychiatrist, Medical Staff, Complejo Asistencial “Benito Menni”

3. Raquel Díaz-Simón MD, Staff Physician, Internal Medicine, Complejo Asistencial “Benito Menni”

4. Francisco López-Muñoz MD PhD, Honorary Professor, Department of Pharmacology, Alcalá University, Madrid, Spain

5. Cecilio Alamo MD PhD, Professor, Department of Pharmacology, Alcalá University

6. Gabriel Rubio MD PhD, Honorary Professor, Department of Psychiatry, Autónoma University, Madrid

Abstract

OBJECTIVE: To present a single case of zuclopenthixol-induced priapism and a literature review. CASE SUMMARY: We report the case of a 31-year-old patient hospitalized due to behavioral alterations and treated with oral zuclopenthixol, an antipsychotic from the thioxanthene family, who developed an acute, painful erection. DISCUSSION: The occurrence of priapism in our patient was related to zuclopenthixol. This adverse reaction is reported for the first time in a patient not concomitantly treated with other drugs associated with the appearance of priapism. The capacity of zuclopenthixol to induce priapism is thought to be due to its antagonist activity on α-adrenergic receptors. CONCLUSIONS: Priapism is an uncommon but potentially serious adverse effect of zuclopenthixol that practitioners, as with many other antipsychotics, should be aware of.

Publisher

SAGE Publications

Subject

Pharmacology (medical)

Link

http://journals.sagepub.com/doi/pdf/10.1345/aph.1A355

Reference26 articles.

1. Association of Priapism in Phenothiazine Therapy

2. Priapism and Psychotropic Medication

3. Priapism and neuroleptics: A case report

4. Perphenazine-Induced Priapism

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