Interaction of Colony-Stimulating Factors and Fluorodeoxyglucose F18 Positron Emission Tomography

Author:

Mayer Dmitri1,Bednarczyk Edward M2

Affiliation:

1. Dmitri Mayer BS, at time of writing, Resident, Nuclear Pharmacy Practice, Schools of Pharmacy and Pharmaceutical Sciences, Department of Pharmacy Practice and Medicine, Department of Nuclear Medicine, State University of New York at Buffalo, Buffalo, NY

2. Edward M Bednarczyk PharmD, Clinical Associate Professor of Pharmacy Practice, Nuclear Medicine, Schools of Pharmacy and Pharmaceutical Sciences, Department of Pharmacy Practice and Medicine, Department of Nuclear Medicine, State University of New York at Buffalo

Abstract

OBJECTIVE: To evaluate reports of altered diagnostic images with fluorodeoxyglucose F18 (FDG) positron emission tomography (PET) after treatment with colony-stimulating factors (CSFs). DATA SOURCES: Literature was identified by a MEDLINE search (1966–December 2001). Key search terms included granulocyte colony-stimulating factor, granulocyte—macrophage colony-stimulating factor, macrophage colony-stimulating factor, fluorodeoxyglucose, and emission-computed tomography. English language literature was reviewed. DATA SYNTHESIS: Reports have suggested altered FDG PET images following CSF treatment. Studies that assessed the effect of CSF administration on FDG PET imaging of the bone and bone marrow were reviewed. CONCLUSIONS: Administration of CSFs may interfere with accurate FDG PET imaging. Separating FDG PET imaging from CSF therapy by ≥5 days may diminish this interference.

Publisher

SAGE Publications

Subject

Pharmacology (medical)

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