Insulin Detemir—A New Basal Insulin Analog-Reference-Cited by-同舟云学术

Insulin Detemir—A New Basal Insulin Analog

Published:2005-03 Issue:3 Volume:39 Page:502-507
ISSN:1060-0280
Container-title:Annals of Pharmacotherapy
language:en
Short-container-title:Ann Pharmacother

Author:

Goldman-Levine Jennifer D¹,Lee Karen W²

Affiliation:

1. Jennifer D Goldman-Levine PharmD CDE, Assistant Professor of Pharmacy Practice, Department of Pharmacy Practice, School of Pharmacy—Boston, Massachusetts College of Pharmacy and Health Sciences; Clinical Pharmacy Faculty, Certified Diabetes Educator, Tufts University Family Medicine Residency Program, Boston, MA

2. Karen W Lee PharmD BSChem CDM, Assistant Professor of Pharmacy Practice, Department of Pharmacy Practice, School of Pharmacy—Boston, Massachusetts College of Pharmacy and Health Sciences; Walgreens/MCPHS Community Pharmacy Practice Residency Program, Boston

Abstract

OBJECTIVE: To review the pharmacology, pharmacokinetics, clinical trial data, adverse effects, and role in therapy of insulin detemir. DATA SOURCES: Articles and meeting abstracts were identified through searches of MEDLINE (1996–June 2004), EMBASE (1980–June 2004), and International Pharmaceutical Abstracts (1970–June 2004) databases, and unpublished information was provided by the manufacturer. STUDY SELECTION AND DATA EXTRACTION: All available studies relating to insulin detemir's pharmacology were selected. Only human studies were used for pharmacokinetic, drug interaction, efficacy, and safety data. DATA SYNTHESIS: Insulin detemir is a basal insulin analog that has been shown to improve glycemic control in patients with type 1 and type 2 diabetes. CONCLUSIONS: Insulin detemir offers some benefits over NPH for use as basal insulin in patients with type 1 and type 2 diabetes.

Publisher

SAGE Publications

Subject

Pharmacology (medical)

Link

http://journals.sagepub.com/doi/pdf/10.1345/aph.1E334

Reference39 articles.

1. The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus

2. The Effect of Long-Term Intensified Insulin Treatment on the Development of Microvascular Complications of Diabetes Mellitus

3. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)

4. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)

5. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38

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