Abstract
To study the features of enzymatic and metabolic support of oxidative homeostasis in patients with hypoxic-ischemic brain lesions before and after cardiac surgery using artificial circulation we examined 38 patients, in particular: ischemic stroke — 14 people, encephalopathy — 15 people, severe cognitive dysfunction — 9 people ; diagnosis of neurological status was performed according to clinical protocols. Clinical and biochemical study was performed at the preoperative (3—5 days) and postoperative (5—7 days) stages: determined the content of superoxide dismutase, glutathione peroxidase, catalase in erythrocytes and α-tocopherol acetate in the serum of the blood, as well as the product cells: diene conjugates, metabolites of nitritanion in plasma. Variation statistics, probabilistic distribution of data with the subsequent estimation of reliability of results are applied; relative biochemical parameters were used: metabolic index, metabolic coefficient and metabolic effect for each. Standard methods using the program adapted to the “Excel” environment were used for calculations. The obtained data support the formation of patients with specific postoperative enzymatic-metabolic support of oxidative homeostasis, which should be considered as one of the triggers of hypoxic-ischemic brain lesions. In particular, at the level of the enzymatic chain of pro-, antioxidant protection and at the level of metabolic processes associated with peroxidation of phospholipids of cell membranes, a number of significant metabolic effects were revealed, which are generalized due to secondary oxidation products and NO‑dependent metabolites.
Publisher
Public Organization Association of Neurologists, Psychiatrists and Narcologists of Ukraine
Reference11 articles.
1. Todurov B. M., Kuzmych I. M., Tarabrin O. O. Porushennia funktsii tsentralnoi nervovoi systemy pislia operatsii zi shtuchnym krovoobihom u patsiientiv z nyzkoiu fraktsiieiu vykydu livoho shlunochka // Klinichna anesteziolohiia ta intensyvna terapiia, № 2(6), 2015. S. 82-90.
2. Minimized extracorporeal circulation does not impair cognitive brain function after coronary artery bypass grafting / D. Reineke, B. Winkler, T. Konig [et al.] // Interactive Cardiovascular and Thoracic Surgery. 2015. Vol. 20 (1). P. 68—73.
3. Mankovskyi D. S. Hipoksychno-ishemichni urazhennia holovnoho mozku: prohnostychna tsinnist kliniko-anamnestychnykh faktoriv dlia otsinky yikh ryzyku pry kardiokhirurhichnykh vtruchanniakh z vykorystanniam shtuchnoho krovoobihu / D. S. Mankovskyi // The world of science and innovation. 12th International scientific and practical conference (01-03 July 2021, London, United Kingdom). Cognum Publishing House. London, United Kingdom. 2021. P. 232-237.
4. Mankovskyi D. S. Tserebralnyi krovoobih ta faktory ryzyku formuvannia hipoksychno-ishemichnykh urazhen holovnoho mozku u kardiokhirurhichnykh patsiientiv pry vykorystanni shtuchnoho krovoobihu / D. S. Mankovskyi // Zbirnyk tez naukovykh robit mizhnar. naukovo-prakt. konferentsii (m. Kyiv, 9—10 lypnia 2021r.). Kyiv. HO «Kyivskyi medychnyi naukovyi tsentr», 2021. S. 22-26.
5. An N. Difficulties in Understanding Postoperative Cognitive Dysfunction / N. An, W. F. Yu // Journal of Anesthesia & Perioperative Medicine. 2017. Vol. 4. P. 87-94.