Neuroethological analysis of the features of aggressive and submissive behavior of rats with alcohol dependence during the action of intranasally administered progesterone

Abstract

The aim of the work was to study in a chronic experiment the effect of intranasal progesterone administration on the specifics of behavioral (aggressive and submissive) reactions of rats with alcohol dependence during agonistic encounters. It was shown that the intranasal administration of progesterone to aggressive rats with alcohol dependence under conditions of long-term psychoemotional consequences of zoosocial confrontational interactions led to a decrease in aggressive motivational reactions (the number and total time of attacks); rats with a subordinate type of behavior with alcohol addiction — to a decrease in quantitative and time indicators of passive-defensive behavior. The features of the anxiolytic and hypnotic effects of progesterone on the emotional behavior of aggressive and submissive rats with alcohol dependence were revealed. Key words: alcohol dependence, intranasal administration of progesterone, agonistic collisions