The effectiveness of rehabilitation programs for the mobilization of compensatory-adaptive neuroplasticity processes in patients with Parkinson’s disease according to indicators of neurotrophic factors

Abstract

The purpose of the study: is to objec- tively evaluate the effectiveness of non- drug rehabilitation programs for patients with Parkinson’s disease (PD) based on in- dicators of specific neurotrophic factors. Sixty-one patients with PD: study group — 33 patients, comparison group — 28 people. There were 33 patients in the ex- perimental group and 28 in the compari- son group. The patients of the experi- mental group did daily physical exercises for two months, unlike the representatives of the comparison group. Patients of both groups were examined for the serum level of the neurotrophic fac- tors: glial cell line-derived neurotrophic factor (GDNF) and cerebral dopamine neurotrophic factor (CDNF) In patients with PD of the comparison group, the synchronous dynamics of CDNF and GDNF indicators occurred and char- acterized the individual course of the dis- ease. On the other hand, in the experimental group, asynchrony of changes of these neuro- trophic factors in blood serum was observed under conditions of physical exertion. Summarizing the data obtained, it is nec- essary to consider many factors that can af- fect the level of neurotrophic factors. There is probably a genetically determined hetero- geneity of the Parkinson’s disease pheno- type, which is also expressed by the features of the synchronous dynamics of CDNF and GDNF parameters. It follows that the initial assessment of these parameters in patients with PD is optimal to identify those for whom motor rehabilitation will cause a long and stable positive effect and ensure the course of the disease according to a favourable type. The multidirectional and asynchrony of changes in neurotrophic factors in blood serum under conditions of physical exer- tion indicates the "sensitivity" of the sys- tem of neurotrophic factors to rehabilitation measures, even if they are used for a short time. Since long-term rehabilitation programs provide positive dynamics in the design of neurotrophic factors, a sufficient dura- tion and regularity of non-drug rehabilitation programs are advisable.