Morphologic Spectrum of Neuroendocrine Tumors of the Prostate: An Updated Review

Abstract

Context.— The incidence of neuroendocrine tumors of the prostate increases after hormonal therapy. Neuroendocrine tumors possess a broad spectrum of morphologic features and pose challenges in the pathologic diagnosis and clinical management of patients. Objective.— To present a brief updated summary of neuroendocrine tumors of the prostate with an overview of their histopathologic and immunohistochemical profiles and differential diagnoses. Data Sources.— Literature review, personal experience in the daily practice of pathologic diagnosis, and laboratory research. Conclusions.— Our understanding of neuroendocrine tumors of the prostate classification and diagnosis continues to evolve. These advances benefit the risk stratification and management of prostate cancer.