Cutaneous Spindle Cell Neoplasms: Pattern-Based Diagnostic Approach

Abstract

Context.— Spindle cell neoplasms arising in the skin comprise a heterogeneous group of tumors with divergent lineages. Cutaneous spindle cell neoplasms are relatively common and present surgical pathologists with diagnostic challenges. Recognition of their histopathologies is important for correct diagnosis and management. The current review presents a pattern-based diagnostic approach to common cutaneous spindle cell neoplasms that often cause diagnostic difficulties. Objective.— To provide a useful guide for diagnosis of cutaneous spindle cell neoplasms. Data Sources.— PubMed (US National Library of Medicine) reports and the authors' personal experiences are reviewed. Conclusions.— The authors briefly summarize the histologic features and differential diagnoses of common cutaneous spindle cell neoplasms.