Plasma Cell Granuloma of the Thyroid: Review of an Uncommon Entity

Author:

Patil Pallavi A.,DeLellis Ronald A.1

Affiliation:

1. From the Department of Pathology, Warren Alpert Medical School of Brown University, Lifespan Academic Medical Center, Providence, Rhode Island.

Abstract

Plasma cell granuloma (PCG) is characterized by proliferation of polyclonal plasma cells with associated fibrosis and is often considered part of the heterogeneous group of inflammatory myofibroblastic tumors (IMTs). The thyroid is rarely affected by PCG. A patient having PCG associated with Hashimoto thyroiditis (HT) prompted our literature search that revealed 18 cases of PCG, 55% (n = 10) of which occurred together with HT. The etiopathogenesis of PCG is unknown and there is no specific treatment except surgical excision for compressive symptoms. This entity has an excellent prognosis with no evidence of recurrence or metastasis. Lesions of the thyroid with infiltrating plasma cells include HT, fibrous variant of HT, plasmacytoma, plasma cell myeloma, Riedel thyroiditis, IgG4 (immunoglobulin G4)-related disease, IMT, and PCG. Inflammatory myofibroblastic tumor has ALK gene rearrangements and is considered a neoplasm as opposed to PCG, which is a reactive polyclonal plasma cell proliferation. We believe IMT and PCG are distinct entities and consensus definitions are required for avoiding confusion in the literature.

Publisher

Archives of Pathology and Laboratory Medicine

Subject

Medical Laboratory Technology,General Medicine,Pathology and Forensic Medicine

Cited by 6 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Plasma cell granuloma middle ear: A rare lesion at a rare site;Indian Journal of Pathology and Oncology;2024-09-15

2. Role of myofibroblasts in oral plasma cell granuloma: Immunohistochemical evaluation of α-SMA and ALK in a retrospective study of 30 cases;Journal of Stomatology, Oral and Maxillofacial Surgery;2023-12

3. Thyroid Gland;Non-Neoplastic Disorders of the Endocrine System;2022-11

4. Analgesic, anti-inflammatory and acute oral toxicity profile of leaf and bark extracts of Albizia procera;BMC Complementary Medicine and Therapies;2022-02-25

5. Cross-segment spinal plasma cell granuloma:a case report;BMC Musculoskeletal Disorders;2020-11-12

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