Adrenal Cortical Adenoma With Adrenalin-Type Neurosecretory Granules Clinically Mimicking a Pheochromocytoma

Author:

Ivsic Tomislav1,Komorowski Richard A.1,Sudakoff Gary S.1,Wilson Stuart D.1,Datta Milton W.1

Affiliation:

1. From the Departments of Pathology (Drs Ivsic, Komorowski, and Datta), Radiology (Dr Sudakoff), and Surgery (Dr Wilson), Medical College of Wisconsin, Milwaukee, Wis

Abstract

Abstract Adrenal tumors often present with clinical features that are specific and unique to their endocrine metabolism. When these features are in conflict with the pathologic appearance of the tumor, there can be great consternation for both the pathologist and the surgeon. In the case reported herein, an adrenalectomy was performed for clinical features of pheochromocytoma that on gross and histologic examination had the pathologic features of an adrenal cortical adenoma. Electron microscopy subsequently revealed that the tumor cells contained adrenalin-type granules, explaining the clinical outcome. It is crucial for both the surgeon and the surgical pathologist to be aware of this possibility when the clinical and pathologic features of an adrenal tumor are not congruent.

Publisher

Archives of Pathology and Laboratory Medicine

Subject

Medical Laboratory Technology,General Medicine,Pathology and Forensic Medicine

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