Update on Nonneoplastic Pulmonary Lymphoproliferative Disorders and Related Entities

Abstract

Abstract Context.—Recent discoveries have expanded the spectrum of nonneoplastic pulmonary lymphoproliferative disorders and have provided new insights into their pathogenesis and treatment. Objective.—To review the thoracic manifestations of immunoglobulin (Ig) G4–related sclerosing disease and summarize current concepts and differential diagnosis of follicular bronchiolitis, lymphocytic interstitial pneumonitis, and nodular lymphoid hyperplasia. Data sources.—Data sources include recent and old articles, cases from the personal files of the author, and cases borrowed with permission from other authors. Conclusions.—Additional studies will be needed to further refine and add to observations in this evolving area of pulmonary pathology.