Intravascular Large B-Cell Lymphoma

Author:

Davis Joshua W.1,Auerbach Aaron2,Crothers Barbara A.2,Lewin Eleanor3,Lynch David T.4,Teschan Nathan J.4,Schmieg John J.2

Affiliation:

1. From the Clinical and Anatomic Pathology Residency Program, Walter Reed National Military Medical Center, Bethesda, Maryland (Davis).

2. From the Joint Pathology Center, Silver Spring, Maryland (Auerbach, Crothers, Schmieg III).

3. From the Department of Pathology, Women & Infants Hospital, Providence, Rhode Island (Lewin).

4. From the Department of Pathology, Brooke Army Medical Center, Fort Sam Houston, Texas (Lynch, Teschan).

Abstract

Context.— Intravascular large B-cell lymphoma (IVLBCL) is a rare hematopathologic entity, posing both a clinical and histologic challenge for diagnosis. Numerous pitfalls can hinder making the diagnosis. Objective.— To summarize recent developments in literature pertaining to IVLBCL and point out key pitfalls pathologists should be prepared to encounter. Data Sources.— Literature review via PubMed search and hospital (Darnall Medical Library) resources. Conclusions.— The 3 primary pitfalls of IVLBCL include masking of IVLBCL, mimicry by IVLBCL, and mimicry of IVLBCL. These scenarios illustrate the importance of histologic pattern recognition and subsequent usage of immunohistochemistry, especially in context of a clinical history that may be noncharacteristic.

Publisher

Archives of Pathology and Laboratory Medicine

Subject

Medical Laboratory Technology,General Medicine,Pathology and Forensic Medicine

Reference46 articles.

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2. Sheibani K, Battifora H, Winberg CD, et al. Further evidence that “malignant angioendotheliomatosis” is an angiotropic large-cell lymphoma. N Engl J Med. 1986;314(15):943–948.

3. Petroff N, Koger OW, Fleming MG, et al. Malignant angioendotheliomatosis: an angiotropic lymphoma. J Am Acad Dermatol. 1989;21(4):727–733.

4. Swerdlow SH, Campo E, Harris NL, et al, eds. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Revised 4th ed. Lyon, France: IARC;2017. World Health Organization Classification of Tumours; vol 2.

5. Ponzoni M, Campo E, Nakamura S. Intravascular large B-cell lymphoma: a chameleon with multiple faces and many masks. Blood. 2018;132(15):1561–1567.

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