Novel fungicide quinofumelin shows selectivity for fungal dihydroorotate dehydrogenase over the corresponding human enzyme
Author:
Affiliation:
1. Agrochemicals Research Center, Mitsui Chemicals Agro, Inc.
Publisher
Pesticide Science Society of Japan
Subject
Health, Toxicology and Mutagenesis,Insect Science
Link
https://www.jstage.jst.go.jp/article/jpestics/48/1/48_D22-035/_pdf
Reference15 articles.
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2. 2) N. Higashimura, A. Hamada, T. Ohara, S. Sakurai, H. Ito and S. Banba: The target site of the novel fungicide quinofumelin, Pyricularia oryzae class II dihydroorotate dehydrogenase. J. Pestic. Sci. 47, 190–196 (2022).
3. 3) M. E. Jones: Pyrimidine nucleotide biosynthesis in animals: Genes, enzymes, and regulation of UMP biosynthesis. Annu. Rev. Biochem. 49, 253–279 (1980).
4. 4) R. A. G. Reis, F. A. Calil, P. R. Feliciano, M. P. Pinheiro and M. C. Nonato: The dihydroorotate dehydrogenase: Past and present. Arch. Biochem. Biophys. 632, 175–191 (2017).
5. 5) H. M. Lehmann, P. O. Vidalain, F. Tangy and Y. L. Janin: On dihydroorotate dehydrogenases and their inhibitor and uses. J. Med. Chem. 56, 3148–3167 (2013).
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