Synthesis, biological activity evaluation and molecular docking studies of novel thiazole derivatives-Reference-Cited by-同舟云学术

Synthesis, biological activity evaluation and molecular docking studies of novel thiazole derivatives

Published:2023-04-24 Issue:1 Volume:2 Page:1-24
ISSN:2822-5333
Container-title:European Journal of Life Sciences
language:en
Short-container-title:Eur J Life Sci

Author:

Osmaniye Derya¹^ORCID,Kayiş Uğur²^ORCID,Gül Ülküye Dudu²^ORCID,Özkay Yusuf¹^ORCID,Kaplancıklı Zafer Asım¹^ORCID

Affiliation:

1. ANADOLU UNIVERSITY

2. BILECIK SEYH EDEBALI UNIVERSITY

Abstract

Resistance to existing drugs develops because of insensible use of antibacterial and antifungal drugs. Therefore, there is a need for the development of new drug candidate compounds. The thiazole ring has many biological activities. It is possible to include antibacterial and antifungal activities among these activities. In addition to these, the thiazole ring has been preferred because it is the bioisostere of the imidazole ring in the structure of many antifungal drugs. For this purpose, within the scope of this study, 7 new thiazole compounds were synthesized, and their structure determinations were carried out using HRMS, 1H-NMR, 13C-NMR spectroscopic methods. Their antibacterial and antifungal activities were investigated by in vitro methods. As a result of activity tests, compound 3e showed activity against C.krusei strain with MIC50=31.25 ug/mL. The potential effectiveness of the compound 3e on the 14alpha-demethylase enzyme (PDB ID:3LD6) was tested by in silico studies.

Publisher

Anadolu University Health Sciences Institute

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