Synthesis and characterization of new Piperazine-Dithiocarbamate compounds as potent MAO-A inhibitors-Reference-Cited by-同舟云学术

Synthesis and characterization of new Piperazine-Dithiocarbamate compounds as potent MAO-A inhibitors

Published:2022-04-29 Issue:1 Volume:1 Page:1-7
ISSN:2822-5333
Container-title:European Journal of Life Sciences
language:en
Short-container-title:Eur J Life Sci

Author:

Osmaniye Derya¹,Saglik Begüm Nurpelin¹,Levent Serkan¹,Özkay Yusuf¹,Kaplancıklı Zafer Asım¹

Affiliation:

1. ANADOLU ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ, ECZACILIK MESLEK BİLİMLERİ BÖLÜMÜ, FARMASOTİK KİMYA ANABİLİM DALI

Abstract

Monoamine oxidase (MAO) enzymes have an important place in neurodegenerative diseases. While MAO-A inhibitors are used in depression; MAO-B enzyme has an important place in Parkinson's disease. Within the scope of this study, 7 new piperazine-dithiocarbamate derivative compounds were synthesized. Structure determinations of the compounds were performed using 1H-NMR, 13C-NMR and HRMS spectroscopic methods. The MAO inhibitory activities of the compounds were determined by in vitro fluorometric methods. According to the obtained results, compound 2d with IC50=0.108±0.004 µM; compound 2e exhibited inhibitory activity with an IC50=0.074±0.003 µM.

Publisher

Anadolu University Health Sciences Institute

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