THE COMPARATIVE CHARACTERISTIC OF FUNCTIONAL ACTIVITY PERITONAL MACROPHAGES AT IMMUNE DAMAGE OF A LIVER OF CELLULAR AND ANTIBODY GENESIS IN MICE

Abstract

The aim of present work was to compare the functional activity of peritoneal macrophages (Mf) at T-cellular and antibody in­duced hepatitis in mice of CBA line. T-cellular hepatitis was caused by concanavalin A (ConA), antibody-induced hepatitis was caused by administration of xenogenic anti-liver antibo­dies: gamma-globulin fractions of antihepatocytotoxic serum (g-AHCS). It was found that single injection of ConA or g-AHCS caused damage of liver with cytolytic syndrome through 20 hours. Functional activity of Mf in these conditions was sig­nificantly different. Application of ConA resulted in the decrease in phagocytosis of latex particles and oxygen-dependent me­tabolism; application of g-AHCS - to increase of these processes. Weakening of Mf activity may be one of the reasons for the decrease of dead cell eliminations that results in the maintenance of inflammatory reaction. At the same time significant amplification of phagocytic Mf activity may be one of the path­ways of free radical endogenic sources increase that causes cell alteration and plays its role as mediators at inflammation.