Author:
Bubnovskaya L.М., ,Goncharenko A.I.,Ganusevich I.I., ,
Abstract
Summary. The authors have reviewed, analyzed, and summarized data from scientific literature concerning the issue of the influence of dysfunctional adipose tissue on microenvironment and course of oncological disease in overweight patients. We presented an epidemiological data about connection between obesity and survival rates of cancer ill patients. Phenomena of ’obesity paradox’ and basic characteristics of hypertrophic fatty tissue were described in this paper. We inspected the role of intratumoral hypoxia, tumor-associated adipocytes, tumorinfiltrating lymphocytes, and homing protein CXC4R in the formation of aggressive phenotype of a malignant tumor during obesity.
Publisher
National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)
Subject
Materials Chemistry,Economics and Econometrics,Media Technology,Forestry