PROSPECTS OF USING microRNAs AS PREDICTIVE MARKERS OF HORMONE-DEPENDENT BREAST CANCER

Abstract

Summary. Hormone-dependent malignant neoplasms are the most common form of breast cancer (BC) worldwide. The high heterogeneity of clinical manifestations and response to treatment indicates the need to search for prognostic and predictive markers to predict the aggressiveness of the course of hormone-dependent BC and prescribe individualized treatment tactics. MicroRNAs are short RNA molecules that play an important role in regulating the expression of many genes. This is due to the fact that miRNAs are important modulators of growth, differentiation and metastasis of malignant neoplasms of various histogenesis, including BC. MicroRNAs can be used to predict the course of the disease and choose optimal treatment tactics, since their levels can be determined not only in tumor tissue but also in blood serum. The systematization and generalization of the results of our own research and data from the literature on the possibility of using miRNA as predictive markers of hormone-dependent BC indicates the perceptiveness of using miRNA to monitor the course of the tumor process and to determine the sensitivity of tumors to neoadjuvant hormonal therapy.