RADIATION THERAPY OF CERVICAL CANCER PATIENTS: VIEW OF RADIOBIOLOGISTS

Abstract

Summary. Despite the positive results achieved in recent years in the treatment of cervical cancer (CC), the overall and recurrence-free survival of patients with this pathology leaves much to be desired. This is connected with a number of problems. The main ones are late diagnosis, which leads to the neglect of the tumor process, insufficient effectiveness of conservative treatment methods, which depends on relatively low sensitivity to the drugs used, and low specificity of the radiation therapy (RT) used. Based on the analysis of data from the literature and our own research, the way to determine among the main radiobiological indicators, which take into account the mechanisms and stages of the formation of radiation lesions, predictors of complications due to RT in CC patients. This will make it possible to single out a group at increased risk of developing negative effects of RT, to develop effective means of pathogenetic therapy for tissue damage from around the tumor, and thus to reduce the frequency, nature and degree of severity of remote side complications of RT in this category of patients, which will contribute to improving the quality of life of patients.