Author:
Petrushenko M.A., ,Petrushenko E.A.,Lukyanetz E.A., ,
Abstract
In mammals, the ankyrin ionotropic transient receptor potential type 1 (TRPA1) is the only member of the TRPA receptor gene subfamily. It is defined as a target for damaging and inflammatory effects in peripheral sensory neurons, which implies its functional role in the development of pain and neurogenic inflammation. Experimental studies indicate that calcium permeable non-selective ion receptor channel TRPA1 is activated by a number of exogenous irritant compounds, factors including low temperatures. This review describes the structure, properties, and physiological role of TRPA1 receptors.
Publisher
National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka)