PLANT RAW MATERIAL AS A SOURCE OF METABOLITES FOR WOUND HEALING AND ANTI-SCARRING PRODUCT

Abstract

Cosmeceutical products based on plant raw materials have a complex effect, are available, and low-toxic. The creation of new natural products for wound healing without tissue scarring is topical. For this, the secondary metabolites of the plant must demonstrate antibacterial, anti-inflammatory, and antioxidant effects, and have low cytotoxicity. Aim. To conduct an analysis of literary sources in electronic databases, regarding products on the market with a wound healing effect and plant raw materials that would have a therapeutic effect on wound healing without the formation of scars. Results. The characteristics of four types of scars are described. Plants and secondary metabolites are listed according to their action: antibacterial, antioxidant, anti-inflammatory, collagenstimulating, and anti-scarring. Lupeol, allicin, and cinnamaldehyde show antibacterial effect; quercetin, resveratrol, luteolin, naringenin, gallic acid, and curcumin show antioxidant effect; asiatic acid, pinocembrin, and myricetin show anti-inflammatory effect. Cryptotanshinone, bexarotene, taspine, sesamol, and astragaloside IV contribute to the deposition of fresh collagen in the wound. On the Ukrainian market, there are natural wound healing products in the form of a balm, cream, and gel. They include vegetable oils, essential oils, extracts of Thymus L., Arnica montana, Inula helenium, Aloe vera, Matricaria chamomilla, etc. Wound healing medicinal products of a chemical nature occupy a large part of the Ukrainian market, among them the products with dexapentanol predominate. The use of the cell culture method as an alternative source of plant raw materials for wound and scar treatment is perspective. The biotechnological method helps preserve biodiversity and obtain chemically pure plant raw materials regardless of environmental conditions. Conclusions. The study demonstrates the possibilities of using plant raw materials to create new cosmeceuticals with wound healing and anti-scaring effects for use in combined therapy.