Abstract
Liposomal drug delivery system is an example of the use of nanodrugs in medical practice. Encapsulation of active pharmaceutical ingredients in liposomal nanoparticles allows increasing their bioavailability and efficacy. Aim. The article is devoted to the analysis of the lipid composition of liposomal drugs developed in Ukraine, its influence on the choice of technology and control parameters. Results. The lipid compositions of liposomal drugs developed in Ukraine in recent years were reviewed. The advantages and disadvantages of natural phosphatidylcholine as the main membrane-forming lipid were analyzed. Data on the influence of anionic phospholipids and cholesterol in the liposomal membrane composition on the stability of liposomal nanoparticles and the level of active pharmaceutical ingredient encapsulation were given. The main technological stages of obtaining liposomes with hydrophilic and hydrophobic active pharmaceutical ingredients were considered. The main groups of quality indicators of liposomal dosage forms have been determined. Conclusions. The lipid composition determines the structure and physicochemical properties of the lipid membrane, the mechanism and level of active pharmaceutical ingredient encapsulation, which significantly influences the pharmacological efficacy of liposomal drug delivery systems.
Publisher
National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)
Subject
General Earth and Planetary Sciences,General Environmental Science
Reference40 articles.
1. 1. Rommasi F, Esfandiari N. Liposomal nanomedicine: applications for drug delivery in cancer therapy. Nanoscale Res. Lett. 2021, 16(1), 95. https://doi:10.1186/s11671-021-03553-8
2. 2. Shvets V.I., Krasnopolskiy Yu.M., Sorokoumova G.M. Liposomal forms of drugs: technological features of production and use in the clinic. M.: Remedium, 2016. 200 p. (In Russian).
3. 3. Bulbake U., Doppalapudi S., Kommineni N., Khan W. Liposomal formulations in clinical use: an updated review. Pharmaceutics. 2017, 9(2), 12. https://doi.org/10.3390/pharmaceutics9020012
4. 4. Allen T. M., Cullis P. R. Liposomal drug delivery systems: from concept to clinical application. Adv. Drug. Deliv. Rev. 2013, 65(1), 36-48. https://doi.org/10.1016/j.addr.2012.09.037
5. 5. Khromov A. S. Liposomal drugs - implementation of nanotechnology in medicine. Pharmacol. Drug Toxicol. 2016, 2(48), 14-23. (In Russian).