THE INFLUENCE OF PHOTOSENSITIVE PEPTIDOMIMETICS ON WEIGHT INDICES OF IMMUNE ORGANS OF EXPERIMENTAL ANIMALS WITH TRANSPLANTABLE LEWIS LUNG CARCINOMA

Abstract

The use of photodynamic therapy of drugs capable of selective accumulation in the tumor or in affected cells, in particular photosensitive peptidomimetics, increases its effectiveness in various treatment schemes. Aim. Determination of weight indices (WI) of thymus and spleen in animals with carcinoma after photodynamic therapy with peptidomimetics: LMB002 and LMB033. Methods. Studies of WI of immune organs were carried out in mice of the C57 Black line on the 28th day after transplantation of Lewis lung carcinoma. The therapeutic effect was studied using photosensitive peptidomimetics: LMB002 and LMB033. The natural antibiotic gramicidin C was used as a control. Results. Comparison of the WI of the spleen of intact animals and animals with tumors showed a twofold (p< 0.05) increase in animals with tumors. As for the WI of the thymus, a tendency to its increase was observed in animals with tumors, compared to intact ones, but no significant difference was found. The following results were obtained: a decrease in the WI of the spleen in animals with tumors and the introduction of placebo and an increase in the WI of the spleen in animals treated with gramicidin C; an increase in spleen WI and a slight decrease in thymus WI under the influence of LMB002, an increase in spleen WI under the influence of LMB033, while the thymus WI did not change. Conclusions. It was established that the WI of the spleen during therapy with photosensitive peptidomimetics LMB033 and LMB002 increased in all groups of experimental animals compared to intact ones. The most significant effect on the spleen index was observed for the schemes of double administration of LMB033 and double phototherapy. No significant changes in the weight index of the thymus during therapy with photosensitive peptidomimetics LMB033 and LMB002 were found.