The contribution of some biologically active substances of adipose tissue to the development of cardiovascular complications in comorbid patients.

Abstract

The contribution of some biologically active substances of adipose tissue to the development of cardiovascular complications in comorbid patients. Adipose tissue hormones — adipokines — vaspin and omentin, which control homeostasis, lipid and glucose metabolism, have attracted scientific interest in recent years. The purpose of the study was to determine the contribution of some hormones of adipose tissue, namely, vaspin and omentin, in the development of obesity in patients with coronary heart disease with concomitant obesity. Materials and methods. A comprehensive examination of 38 patients with coronary heart disease in combination with obesity (average age: 64±1.9 years), men and women in equal numbers, was conducted; the comparison group consisted of 40 patients with coronary artery disease without obesity. Control group: 20 practically healthy individuals without coronary heart disease and with normal body weight, average age 58.2±1.4 years. Conclusions: The comorbidity of coronary heart disease and obesity leads to the activation of the pro-inflammatory hormone of adipose tissue — vaspin and insufficient circulation of omentin, which leads to an increase in body weight. The development of obesity in patients with coronary heart disease depends on the dysfunction of adipose tissue, the manifestations of which are an imbalance in the levels of vaspin and omentin.