Author:
Yakovtsova Irina, ,Yanchevskyi Oleksandr,
Abstract
Small cell lung cancer (SCLC) is one of the most aggressive tumor of the human body and has morphological features of cancers with epithelial-mesenchymal transformation (EMT). The aim of our study to improve morphological features for SCLC course prediction based on researching of EMT and stem cells phenotype at the molecular-biological level. The prognostic significance of pancytokeratin, vimentin, E-cadherin and N-cadherin expression, EMT stage and expression of CD44 for overall survival and their influence on the spread of the tumor were established. It was proved that the presence of EMT is associated with extensive forms of SCLC (p < 0.01), the overall survival of patients with SCLC depended on the presence of EMT (p < 0.01) and its stage (p < 0.01).
Publisher
National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)
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