Relationships between home blood pressure monitoring parameters and plasma catestatin and relaxin-2 levels in patients with essential hypertension and type 2 diabetes mellitus

Abstract

Objective. To investigate the peculiarities of home blood pressure monitoring parameters in patients with essential hypertension (EH) in combination with type 2 diabetes mellitus (T2DM) and to evaluate their relationships with plasma catestatin (CTS) and relaxin-2 (RLN-2) levels. Materials and methods. 106 patients with EH, 55 of whom had comorbidity T2DM, and 30 healthy volunteers were enrolled in the study. Each patient underwent a comprehensive clinical examination, including measurement of systolic (SBP) and diastolic (DBP) blood pressure. Each study subject carried out home blood pressure monitoring for 31 days with the further registration of indicators in a diary. The levels of CTS and RLN-2 were determined by the enzyme-linked immunosorbent assay. Statistical data analysis was performed using the SPSS 25.0 statistical software. Results. CTS levels were reduced in patients with high normal SBP and arterial hypertension (p<0.001). There were revealed significant negative correlations of CTS levels with home blood pressure monitoring parameters (p<0.05). In patients with levels of RLN-2≥4.69 pg/ml, there were observed higher SBP (p<0.001) and DBP (p<0.05) parameters, except average and morning DBP. Conclusions. The decrease in CTS levels in EH and established correlations between CTS and home blood pressure monitoring parameters allow us to consider CTS as a biomarker of EH, especially EH with T2DM.