Modern aspects of pathogenesis of comorbidity of non-alcoholic fatty liver disease and hypertension in the presence or absence of chronic kidney disease.

Abstract

The article presents the main aspects of the pathogenesis of comorbidity of non-alcoholic fatty liver disease and hypertension. These diseases are very often presented as comorbidities in a large number of patients and can independently impair renal function. According to the literature and the results of our own research, the role of insulin resistance, disorders of lipid and carbohydrate metabolism, cytokine imbalance, disorders of the antioxidant defense system in the pathogenesis of this comorbidity was analyzed. The effect of hypoadictinemia and increased blood levels of fetuin-A and cytokeratin-18 on this comorbidity was also assessed. The independent effect of non-alcoholic fatty liver disease on renal function, arterial stiffness and the occurrence of diastolic heart function was analyzed. The interaction between non-alcoholic fatty liver disease and hypertension depending on the presence of chronic kidney disease was also evaluated. Key words: nonalcoholic fatty liver disease, hypertension, pathogenesis, comorbidity, renal impairment.