The problem of osteoporosis in general medical practice: prevalence, risk factors, genetic predictors. Role of chronic pancreatitis and hypertensive disease in the formation of secondary osteoporosis

Abstract

The combination of socially significant common chronic non-infectious diseases of internal organs, the interaction of their pathogenetic links quite often leads to the development of complications that affect the course of the main nosology. Among these tandems, chronic pancreatitis and hypertension are considered — calcium-dependent diseases, the comorbidity of which can affect the disturbances in calcium metabolism, thereby contributing to the formation of osteopenic conditions. A number of researchers have established that the development of diseases such as chronic pancreatitis and hypertension, and their complications (namely, osteoporosis) can be the result of the presence of candidate genes, the unfavorable polymorphism of which can provoke changes in the pathogenetic directions of the diseases course.