HEPATOTROPIC EFFECTS OF TRIPLE ANTIULCER THERAPY AND PLACENTA CRYOEXTRACT: THE ROLE OF SEX FACTORS IN LIPOPEROXIDATION

Abstract

The purpose of the work was to reveal the role of sex factors in the processes of lipid peroxidation (LPO) against the background of chronic ethanol-tetrachloromethane-induced liver damage and the hepatotropic effects of triple antiulcer therapy and cryopreserved placenta extract (CEP). Chronic ethanol-tetrachloromethane-induced liver damage was induced by the introduction of a CCl4 solution in combination with an ethanol solution for 45 days. The content of reactants with thiobarbituric acid (TBA-active products) and catalase activity were measured in liver homogenates. Modulation of the content of sex hormones was achieved by surgical ovariectomy or testectomy. The study showed that the combined intravenous administration of esomeprazole, clarithromycin and metronidazole to rats with chronic ethanol-tetrachloromethane-induced liver damage caused an inhibition of the antioxidant defense system, this was indicated by a statistically significant decrease in catalase activity by 38.4% and a decrease in the antioxidant-prooxidant index by 35.1%, compared with the parameters of intact rats. The most significant activation of LPO processes was noted in females against the background of chronic ethanol-tetrachloromethaneinduced liver damage and the administration of anti-ulcer drugs after ovariectomy. In this case, the content of TBAactive products was 36.1 ± 2.79 μmol/kg of tissue. It was established that in castrated females, the combined use of anti-ulcer drugs and CEP against the background of chronic ethanol-tetrachloromethane-induced liver damage leveled the activation of LPO processes, this was indicated by a statistically significant (P < 0.001) 2.7 times lower content of TBA-active products in liver homogenates.