Author:
Demchenko O.M., ,Rodynskyi O.G.,Kondratieva O.Yu.,Zaychenko O.Yu., , ,
Abstract
Changes in behavioral and mnestic activity, as well as their neurochemical support in thyroid dysfunction were determined in juvenile Wistar rats. Behavioral activity was studied in an elevated cruciform labyrinth, the study of spatial memory was performed by the development of protective avoidance reaction in the Morris water labyrinth, and by the production of food reactions in the 8-beam labyrinth. The content of free amino acids of the neurotransmitter spectrum and serotonin was determined by thin layer chromatography followed by spectrophotometry. It was found that thyroid dysfunction in early ontogenesis was accompanied by significant impairments of emotional and cognitive activity depending on the thyroid status of rats; differences in the mechanisms of the formation of spatial memory with negative and positive reinforcement were also found. At the same time, the anxiolytic type of behavior and formation of spatial memory in juvenile animals with experimental hyperthyroidism are possibly provided by an increase in GABA content in the neocortex by 40% and a decrease in serotonin level in the hippocampus by 32%. Experimental hypothyroidism caused an anxiogenic effect and cognitive impairment, which were accompanied by an excessive increase by 51% in the neocortical serotonin content.
Publisher
National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka)
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