FILM-FORMING COMPOSITIONS BASED ON POLYURETHANEUREAS WITH EXTENDED RELEASE OF DACARBAZINE

Abstract

Composite materials with dacarbazine (DK) containing 1 wt. % were obtained on the basis of polyurethane ureas (PUU) containing in the structure as extenders of the macrochain of 2-(2-aminoethoxy)ethan-1-amine, (DA1) 3,6-dioxaoctane-1,8-diamine (DA2) 3-{2-[2-(3-aminopropoxy)ethoxy]ethoxy}propan-1-amine (DA3) with a molar ratio of 4,4’-diaminodiphenylmethane (DADPh) to DA1 and DA3 as 30:70; 50:50; 70:30. The tensile strength of the compositions is within (1.21-1.27) MPa, the relative elongation is (303.9-384)%. Studies of thermophysical properties of synthesized PUU by DSC, TGA methods were conducted. Dacarbazine compositions are single-phase systems with glass transition temperature (Tg) from -33.55°C to -37.06°C. It was established that the introduction of Dacarbazine into the composition of PUU leads to a decrease in Tg and ΔCp during the second warm-up in comparison with the original PUU. Dacarbazine compositions are resistant to temperatures of 270oC, which allows for thermal sterilization before use. The release of Dacarbazine from polymer samples into the solution was studied by the spectrophotometric method. According to the results of the study of the dynamics release of Dacarbazine, it was es tablished that for (PUU DA1)2+DK in 14 days it is 61.74%, (PUU DA2)4+DK - 70.09%, (PUU DA3)2+DK - 56.75% of the total amount of immobilized DK. The resulting composites are perspective materials for medicine as means of local prolonged therapeutic action.