Synthesis of novel α-trifluoromethyl cyclobutane-containing building blocks-Reference-Cited by-同舟云学术

Synthesis of novel α-trifluoromethyl cyclobutane-containing building blocks

Published:2022-06-30 Issue:1 Volume:17 Page:81-85
ISSN:1814-9766
Container-title:Ukr. Bioorg. Acta 2022, Vol. 17, N1
language:en
Short-container-title:Ukr. Bioorg. Acta

Author:

Homon Anton¹,Shynder Lada²^ORCID,Hryshchuk Oleksandr²^ORCID,Grygorenko Oleksandr²^ORCID,Kondratov Ivan¹^ORCID

Affiliation:

1. V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine

2. Taras Shevchenko National University of Kyiv

Abstract

Four new cyclobutane-containing building blocks were synthesized on a multigram scale starting from 3-methylene-1-(trifluoromethyl)cyclobutane-1-carbonitrile and 3-methylene-1-(trifluoromethyl)cyclobutane-1-carboxylic acid. The synthesized compounds contain trifluoromethyl group near the functional one (carboxylic or amino group) and are promising for further application in drug discovery

Funder

Enamine

Ministry of Education and Science of Ukraine

Publisher

National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)

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