Exploring aminomethylcoumarins: versatile synthesis, structural diversity, and ADME prediction-Reference-Cited by-同舟云学术

Exploring aminomethylcoumarins: versatile synthesis, structural diversity, and ADME prediction

Published:2023-12-30 Issue:2 Volume:18 Page:22-30
ISSN:1814-9766
Container-title:Ukrainica Bioorganica Acta
language:en
Short-container-title:Ukr. Bioorg. Acta

Author:

Hlibov Eugen K.¹^ORCID,Moskvina Viktoriia S.²^ORCID,Malets Yehor S.³^ORCID,Khilya Volodymyr P.¹^ORCID

Affiliation:

1. Taras Shevchenko National University of Kyiv, Kyiv, Ukraine

2. Taras Shevchenko National University of Kyiv, Kyiv, Ukraine; V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, Kyiv, Ukraine

3. V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, Kyiv, Ukraine

Abstract

This research presents a highly efficient method for synthesizing diverse aminomethylcoumarin libraries through the interaction of Mannich bases of coumarins and primary amines. The developed amination process demonstrated versatility and compatibility with various substituents. Reactions were completed within short timeframes, yielding high-purity products with substantial yields, as well as facilitating the scale-up of the process. The synthesized derivatives exhibited structural diversity, incorporating carboxylic and amino groups, as well as amide, hydrazide, and hydroxamic acid moieties. In silico ADME predictions highlighted the potential of these aminomethylcoumarins as promising candidates for further optimization in the development of oral chemotherapeutic agents

Funder

Ministry of Education and Science of Ukraine

Publisher

National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)

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