Author:
Kharkyanen V.N.,Yesylevskyy S.O.,Berezetskaya N.M.
Abstract
The general theory of the single-file multiparticle diffusion in narrow pores can be greatly simplified in the case of the inverted bell-like shape of a single-particle energy profile, which is often observed in biological ion channels. There is a narrow and deep groove in the energy landscape of multiple interacting ions in such profiles, which corresponds to the pre-defined optimal conduction pathway in the configurational space. If such a groove exists, the motion of multiple ions can be reduced to the motion of a single quasiparticle, called the superion, which moves in a one-dimensional effective potential. The concept of superions reduces the computational complexity of the problem and provides the very clear physical interpretation of conduction phenomena in narrow pores.
Publisher
National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)
Subject
General Physics and Astronomy
Reference19 articles.
1. 1. D.A. Doyle et al., Science 280, 69 (1998).
2. 2. S. Berneche and B. Roux, Nature 414, 73 (2001).
3. 3. B. Hille, Ion Channels of Excitable Membranes(Sinauer Associates, Sunderland, Mass., 2001).
4. 4. G. Hummer, J.C. Rasaiah, and J.P. Noworyta, Nature 414, 188 (2001).
5. 5. F. Zhu and K. Schulten, Biophys. J. 85, 236 (2003).