Biochemical effect of the Biophosphomag medication on the biochemical blood indicators in rats under oxidative stress conditions

Abstract

The study was aimed to examine the effects of the Biophosphomag medication on biochemical parameters of blood under induced oxidative stress in rats. For this purpose, we used 24 animals weighing 200±20 g. The animals were divided into 4 groups of 6 animals in each one and kept on a standard diet with access to water ad libitum. The 1st group was an intact control without oxidative stress and its correction; the 2nd was a control with induced oxidative stress and without its correction. The 3rd group received a 1% solution of magnesium sulfate intragastrically. The animals of the 4th group were administered Biophosphomag (a combined medication of magnesium and phosphorus based on casein) in a dose equivalent to magnesium sulfate by magnesium. Oxidative stress was induced with a single intragastric administration of paracetamol. The results of the serum analysis after the intake of medication showed, on the one hand, a decrease in the activity of the enzymes: alkaline phosphatase, alanine aminotransferase, α-amylase, aspartate aminotransferase, lactate dehydrogenase, glucose and TBA-active compounds concentration (P<0.05), and, on the other hand, an increase in the magnesium concentration and catalase activity. The obtained results indicate a higher bioavailability of magnesium in the composition of the Biophosphomag medication than in the composition of magnesium sulfate, which leads to a more significant hepatoprotective effect under conditions of induced oxidative damage to the liver. They can be an argument why Biophosphomag medication should be used in the correction of pathological processes accompanied by oxidative stress or as a source of magnesium with high bioavailability.