Author:
Shevchenko N. S., ,Krutenko N. V.,Zimnytska T. V.,Voloshyn K. V., , ,
Abstract
This review highlights the current understanding of hypoxia-inducible factors (HIFs) role as regulators of oxygen-dependent reactions and inducers of genes expression in human organism. The focus is on the most significant relationships between the activation or inhibition of the HIFs intracellular system and development of the inflammatory process in various organs, chronic diseases of gastrointestinal tract, osteoarticular system, kidneys as well as hematological, endocrine and metabolic disorders.
Publisher
National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)
Reference59 articles.
1. Loboda A, Jozkowicz A, Dulak J. HIF-1 and HIF-2 transcription factors - similar but not identical. Mol Cells. 2010;29(5):435-442. PubMed, PubMedCentral, CrossRef
2. Pugh CW, O'Rourke JF, Nagao M, Gleadle JM, Ratcliffe PJ. Activation of hypoxia-inducible factor-1; definition of regulatory domains within the alpha subunit. J Biol Chem. 1997;272(17):11205-11214. PubMed, CrossRef
3. Glukhanyuk E. Hypoxia, non-hypoxic hypoxia and immunity. "Biomolecule". Immunology, medicine, cytology. 2015 November. (In Russian). Available at https://biomolecula.ru/articles/gipoksiia-negipoksicheskaia-gipoksiia-i-immunitet.
4. Maes C, Carmeliet G, Schipani E. Hypoxia-driven pathways in bone development, regeneration and disease. Nat Rev Rheumatol. 2012;8(6):358-366. PubMed, CrossRef
5. Wiesener MS, Jürgensen JS, Rosenberger C, Scholze CK, Hörstrup JH, Warnecke C, Mandriota S, Bechmann I, Frei UA, Pugh CW, Ratcliffe PJ, Bachmann S, Maxwell PH, Eckardt KU. Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs. FASEB J. 2003;17(2):271-273. PubMed, CrossRef