Affiliation:
1. aksaray university
2. AKSARAY ÜNİVERSİTESİ
3. AKSARAY UNIVERSITY, AKSARAY VOCATIONAL SCHOOL
Abstract
Medicinal plants are an indispensable source of new and effective pharmaceutical products. In the study, the biological activities of water extract obtained from the H. rosa-sinensis leaf was determined and its potential for use in the pharmaceutical and cosmetic industries was investigated. Disc diffusion assay and micro-dilution method against clinical origin test microorganisms were used to assess biological activity. The Extract showed a zone of inhibition on the tested bacteria and yeasts in the 6.85 mm to 10.74 mm range. MIC and MBC or MFC values of the Extract was determined as 6.25-12.50 µg/µL and 12.50-50 µg/µL. Then, the cream formulation containing H. rosa-sinensis leaf water extract and/or human milk originated probiotic candidate Limosilactobacillus fermentum MA-7 strain have been developed. The Extract and probiotic containing cream formulations showed variable antibacterial and antifungal effects on the tested clinical originated microorganisms. The highest inhibition zone diameters of Cream + Extract + Probiotic formulation group was obtained against Candida glabrata RSKK 04019 (9.09 mm) and Escherichia coli O157:H7 (9.04 mm). The results indicate that L. fermentum MA-7 and H. rosa-sinensis water extract, alternative to synthetic antimicrobials, may be used as a natural bioactive ingredient in daily personal care and clinical applications in the near future.
Publisher
Kyrgyz-Turkish Manas University
Reference27 articles.
1. Aladeboyeje, O., and Şanlı, N. Ö. (2021). Fermented traditional probiotic beverages of Turkish origin: a concise
review. International Journal of Life Sciences and Biotechnology, 4(3), 546-564.
https://doi.org/10.38001/ijlsb.936982
2. Al-Shammari, K. I., Batkowska, J., Gryzińska, M., Wlazło, Ł., Ossowski, M., & Nowakowicz-Dębek, B. (2022). The
use of selected herbal preparations for the disinfection of Japanese quail hatching eggs, Poultry Science,
101(10), 102066. https://doi.org/10.1016/j.psj.2022.102066
3. Al-Zoreky, N. S. (2009). Antimicrobial activity of pomegranate (Punica granatum L.) fruit peels. International
Journal of Food Microbiology, 134(3), 244-248. https://doi.org/10.1016/j.ijfoodmicro.2009.07.002
4. Anil, K., & Ashatha, S. (2012). Review on Hibiscus rosa sinensis. International Journal of Research in
Pharmaceutical and Biomedical Sciences, 3(2), 534-538. http://www.ijrpbsonline.com/files/13-3213.pdf
5. Asan-Ozusaglam, M., & Celik, I. (2023). White pitahaya as a natural additive: potential usage in cosmetic
industry. Foods and Raw materials, 11(1), 57-63. https://dx.doi.org/10.21603/2308-4057-2023-1-552