Electrospun Nanofibers on Applications of Nerve Guide Channel

Abstract

Therapeutic methods developed for the repair of damaged nerves often do not provide adequate recovery. Along with the application of tissue engineering principles in the nerve tissue regeneration, many researches have been made and are still in progress to develop an ideal nerve guide channel. Promising studies are ongoing for the use of nano-sized fibrous scaffolds for nerve tissue repair, which can mimic the topography of the natural extracellular matrix. With the electrospinning method, nanofibers can be produced and the nanofiber nerve channels enabling neuron development and regrowth can be placed in the nerve gap that has lost its function. This study summarizes nerve tissue engineering strategies and clinical practices, including biomaterials and tissue scaffold production techniques to produce a structure that allows neurons to adhere, multiply, and eventually form nerves.